Brain Tumours week 21

Week 21: Brain Tumours : Gliomas

1. What is the commonest glioma?

Glioblastoma multiforme WHO Grade IV. An aggressive tumour which is treated with surgery and if appropriate post operative radiotherapy and chemotherapy, although not all patients are fit for this.

2. What is Temozolamide?

This is an oral alkylating agent which was shown in the practice changing Stupp Trial to add a significant survival advantage to patients compared to radiotherapy alone.

3. What benefit does it bring to glioma patients?

The two year survival was extended from approximately 10% to 25%.

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