Week 14

Week 14: Targeted cancer therapies

1. Give an example of a tyrosine kinase inhibitor? For what tumour type is it indicated in the UK?
Erlotinib, ( trade name Tarceva) is Tyrosine kinase inhibitor which is used in non small cell lung cancer. The names of TKIs usually end in “ib” It targets the epidermal growth factor receptor, and so is also known as an EGFR inhibitor.

2. Give an example of a vascular endothelial growth factor inhibitor (VEFGF) ? For what tumours are these licensed in the UK? Sunitinib is an VEGF inhibitor used to treat metastatic renal cell cancer. It also is a tyrosine kinase inhibitor.

3. Give an example of a monoclonal antibody that is used to treat cancer? Which type of cancer does it treat? Trastuzumab (the names of monoclonal antibodies end in “ab“) also known as Herceptin, targets the Her-2 receptor expressed in some breast cancers, and extends survival. It can be used in the adjuvant setting or palliatively.

Trastuzumab (Herceptin)

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